KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG2
All Species:
23.33
Human Site:
S542
Identified Species:
46.67
UniProt:
P16885
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16885
NP_002652.2
1265
147870
S542
K
K
V
E
K
R
T
S
A
E
K
L
L
Q
E
Chimpanzee
Pan troglodytes
XP_001147944
1265
147906
S542
K
K
V
E
K
R
T
S
A
E
K
L
L
Q
E
Rhesus Macaque
Macaca mulatta
XP_001111677
1265
147898
S542
K
K
V
E
K
R
T
S
A
E
K
L
L
Q
E
Dog
Lupus familis
XP_546812
1252
146274
S542
K
K
V
E
K
R
T
S
A
E
K
L
L
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIH5
1265
147573
S542
K
K
V
E
S
R
T
S
A
E
K
L
L
Q
E
Rat
Rattus norvegicus
P24135
1265
147716
S542
K
K
V
E
S
R
T
S
A
E
K
L
L
Q
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508105
991
115582
I299
N
P
L
S
H
Y
W
I
S
S
S
H
N
T
R
Chicken
Gallus gallus
Q2VRL0
637
72514
Frog
Xenopus laevis
Q32NH8
758
87399
I66
S
T
F
S
I
S
D
I
E
T
V
R
E
G
H
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
E92
T
F
S
V
T
E
V
E
C
V
R
E
G
C
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624101
1134
132613
T442
T
Q
Q
K
L
F
Y
T
D
T
F
S
R
T
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
G248
S
L
S
F
W
A
M
G
K
V
N
H
C
R
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
94.4
N.A.
94.1
94.7
N.A.
62.7
20.7
22.1
21.2
N.A.
N.A.
40.9
N.A.
32.9
Protein Similarity:
100
99.9
99.2
97
N.A.
97.1
97.3
N.A.
67.8
33.2
37.5
34.9
N.A.
N.A.
59.1
N.A.
49
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
0
0
0
0
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
13.3
0
0
13.3
N.A.
N.A.
26.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
0
0
50
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
0
9
9
0
% C
% Asp:
0
0
0
0
0
0
9
0
9
0
0
0
0
0
0
% D
% Glu:
0
0
0
50
0
9
0
9
9
50
0
9
9
0
50
% E
% Phe:
0
9
9
9
0
9
0
0
0
0
9
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
9
0
0
0
0
9
9
0
% G
% His:
0
0
0
0
9
0
0
0
0
0
0
17
0
0
9
% H
% Ile:
0
0
0
0
9
0
0
17
0
0
0
0
0
0
9
% I
% Lys:
50
50
0
9
34
0
0
0
9
0
50
0
0
0
0
% K
% Leu:
0
9
9
0
9
0
0
0
0
0
0
50
50
0
0
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
0
9
0
9
0
0
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
9
0
0
0
0
0
0
0
0
0
0
50
17
% Q
% Arg:
0
0
0
0
0
50
0
0
0
0
9
9
9
9
9
% R
% Ser:
17
0
17
17
17
9
0
50
9
9
9
9
0
0
0
% S
% Thr:
17
9
0
0
9
0
50
9
0
17
0
0
0
17
0
% T
% Val:
0
0
50
9
0
0
9
0
0
17
9
0
0
0
0
% V
% Trp:
0
0
0
0
9
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
9
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _